Philip A Efron Selected Research

Shock

10/2021	Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.
1/2020	Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
1/2018	Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
1/2016	Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.
6/2015	Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation.
4/2013	Identification and description of a novel murine model for polytrauma and shock.
6/2004	Increased lymphoid tissue apoptosis in baboons with bacteremic shock.

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Philip A Efron Research Topics

Disease

63	Sepsis (Septicemia) 03/2022 - 06/2004
46	Wounds and Injuries (Trauma) 01/2022 - 03/2004
28	Inflammation (Inflammations) 01/2022 - 10/2005
22	Critical Illness (Critically Ill) 03/2022 - 01/2017
20	Hemorrhagic Shock 11/2021 - 04/2013
18	Anemia 03/2022 - 10/2016
16	Contusions 01/2022 - 01/2017
11	Infections 01/2022 - 11/2010
8	Acute Kidney Injury (Acute Renal Failure) 11/2021 - 04/2013
7	Shock 10/2021 - 06/2004
6	Coinfection 10/2021 - 11/2010
5	Neonatal Sepsis 01/2021 - 07/2011
5	Neoplasms (Cancer) 01/2017 - 06/2006
4	Hemorrhage 01/2021 - 04/2013
4	Pneumonia (Pneumonitis) 01/2018 - 02/2016
3	Bacterial Infections (Bacterial Infection) 01/2022 - 08/2006
3	Multiple Trauma (Multiple Injuries) 10/2021 - 04/2013
3	Multiple Organ Failure (MODS) 01/2018 - 03/2012
3	Appendicitis 01/2018 - 01/2017
3	Kidney Diseases (Kidney Disease) 01/2018 - 11/2013
2	Muscular Diseases (Myopathy) 01/2021 - 01/2018
2	Disease Progression 01/2021 - 06/2012
2	Iron Deficiencies 12/2020 - 01/2019
2	Weight Loss (Weight Reduction) 11/2020 - 11/2019
2	B-Cell Lymphoma (Lymphoma, B Cell) 11/2019 - 01/2017
2	Venous Thromboembolism 01/2019 - 08/2011
2	Septic Shock (Toxic Shock Syndrome) 01/2018 - 03/2008
2	Lung Injury 10/2017 - 10/2016
2	Leukocytosis (Pleocytosis) 08/2015 - 01/2014
2	Bacteremia 11/2010 - 09/2005
1	Surgical Wound Infection 01/2022
1	Hernia (Hernias) 01/2022
1	Weight Gain 11/2021

Drug/Important Bio-Agent (IBA)

22	CytokinesIBA 03/2022 - 03/2004
15	lithocholyl-N-hydroxysuccinimideIBA 11/2021 - 10/2016
12	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2018
9	Erythropoietin FDA Link 03/2022 - 10/2016
9	Interleukin-6 (Interleukin 6)IBA 01/2022 - 11/2006
8	Hemoglobins (Hemoglobin)IBA 03/2022 - 01/2017
8	Propranolol (Inderal)FDA LinkGeneric 01/2021 - 01/2017
7	Proteins (Proteins, Gene)FDA Link 10/2021 - 03/2011
6	Interleukin-10 (Interleukin 10)IBA 01/2022 - 06/2005
6	IronIBA 11/2021 - 10/2016
6	LigandsIBA 01/2018 - 10/2005
5	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2021
5	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2020
5	Messenger RNA (mRNA)IBA 01/2022 - 07/2011
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 01/2017
5	Clonidine (ST 155)FDA LinkGeneric 10/2020 - 01/2017
5	AlarminsIBA 01/2020 - 10/2017
5	ChemokinesIBA 11/2019 - 08/2011
4	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2022 - 01/2017
4	Biological ProductsIBA 01/2022 - 03/2008
4	HepcidinsIBA 11/2021 - 10/2016
4	C-Reactive ProteinIBA 10/2021 - 10/2017
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 11/2005
4	CatecholaminesIBA 10/2018 - 10/2016
3	LipopolysaccharidesIBA 01/2022 - 05/2006
3	Erythropoietin Receptors (Erythropoietin Receptor)IBA 11/2021 - 01/2018
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2021 - 01/2017
3	Stem Cell FactorIBA 11/2019 - 01/2017
3	AlbuminsIBA 01/2018 - 01/2014
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2018 - 01/2017
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 03/2004
2	ProcalcitoninIBA 01/2022 - 05/2013
2	Toll-Like Receptor 4IBA 01/2022 - 07/2011
2	Adrenergic Agents (Adrenergic Drugs)IBA 11/2021 - 11/2020
2	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2021 - 01/2019
2	InterleukinsIBA 10/2021 - 01/2019
2	InflammasomesIBA 01/2021 - 06/2015
2	Small Cytoplasmic RNAIBA 01/2021 - 01/2021
2	Mitochondrial DNA (mtDNA)IBA 01/2020 - 01/2019
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2019
2	HMGB1 Protein (HMG1)IBA 11/2019 - 10/2017
2	Pattern Recognition ReceptorsIBA 01/2019 - 10/2017
2	Indicators and Reagents (Reagents)IBA 01/2019 - 05/2013
2	CreatinineIBA 01/2016 - 11/2013
2	CollagenIBA 07/2013 - 11/2005
2	Hydroxyproline (4 Hydroxyproline)IBA 07/2013 - 11/2005
2	salicylhydroxamic acid (SHAM)IBA 04/2013 - 12/2006
2	Toll-Like Receptors (Toll-Like Receptor)IBA 03/2008 - 05/2006
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2022
1	metal transporting protein 1 (ferroportin)IBA 01/2022
1	Transferrin (beta 2 Transferrin)IBA 11/2021

Therapy/Procedure

11	Critical Care (Surgical Intensive Care) 10/2021 - 06/2012
11	Ligation 01/2021 - 09/2004
11	Therapeutics 01/2021 - 03/2008
10	Punctures 01/2021 - 09/2004
10	Resuscitation 01/2020 - 04/2013
8	Length of Stay 11/2021 - 12/2015
7	Laparotomy 02/2019 - 04/2013
5	Blood Transfusion (Blood Transfusions) 01/2021 - 12/2012
4	Artificial Respiration (Mechanical Ventilation) 11/2021 - 12/2015
3	Immunomodulation 04/2021 - 10/2016
3	Appendectomy 01/2018 - 01/2017
2	Immunotherapy 04/2021 - 01/2017
2	Mechanical Ventilators (Ventilator) 01/2021 - 08/2015
2	Long-Term Care 01/2020 - 12/2017
2	Erythrocyte Transfusion 01/2018 - 01/2017
2	Herniorrhaphy 01/2018 - 01/2017